Well, my dad uses it and he's a 72 year old mechanic. No problems with it so far. He didn't even have any computing skills before Ubuntu. What's even more funny, is that he doesn't know how to use Windows. Go figure.
@the artist:
I know how annoying it is that some Windows specific programs do break in WINE--eBay Turbolister being one of them >:( --but for what I can run I'm more than happy with it.